Amino-cyano

Amino-cyano HPLC columns combine amine and nitrile functional groups on one silica, offering a mixed selectivity that sits between a pure amino phase and a pure cyano phase. Method developers reach for them when neither single phase resolves a polar mixture.

The Vintage Chrom Bond Amino Cyano family makes up the 94 listings here, supplied in 125 × 4 mm and 125 × 4.6 mm analytical formats with 3 µm, 5 µm and 10 µm particles on 100 Å silica. The dual functionality lends itself to both normal-phase and reversed-phase conditions depending on the eluent.

Start with the 5 µm column for routine work and step down to 3 µm when you need extra resolution from the same length. The wider 4.6 mm bore suits standard HPLC flow rates, while 4 mm reduces solvent use slightly. Questions about a specific separation are welcome.